I've been having a hard time getting the Uniden SDS100 serial over USB to work with my Windows virtual machine, but finally figured it out.
My virtual machine setup
Host Machine
Using VirtualBox with Oracle VM VirtualBox Extension Pack installed. The first thing you'll want to do after installing the Oracle VM VirtualBox Extension Pack is to enable USB via the virtual machine's settings. I selected USB 3.0, but depending on your use case, you may have to try another option.